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FOXF2 is a downstream target of miR-519a in HCC cells. (A) The 3′-UTR of FOXF2 mRNA was found to contain the complementary sequence of miR-519a. (B) Overexpression of miR-519a significantly suppressed the luciferase activity of wt 3′-UTR of FOXF2 but not mt 3′-UTR of FOXF2. Down-regulation of miR-519a resulted in an obvious increase in luciferase activity of wt 3′-UTR of FOXF2. n = 3 repeats with similar results; ∗P < 0.05.
