Table 1.
Clinicopathological correlation analyses of miR-519a expression in HCC.
| Clinicopathologic features | Total no. of patients, n = 80 | No. of patients |
P | ||
|---|---|---|---|---|---|
| High miR-519a | Low miR-519a | ||||
| Age (y) | ⩽50 | 32 | 15 | 17 | 0.648 |
| >50 | 48 | 25 | 23 | ||
| Sex | Male | 67 | 34 | 33 | 0.762 |
| Female | 13 | 6 | 7 | ||
| HBsAg positive | No | 20 | 4 | 16 | 0.002⁎ |
| Yes | 60 | 36 | 24 | ||
| Serum AFP level (ng/mL) | ⩽20 | 24 | 10 | 14 | 0.329 |
| >20 | 56 | 30 | 26 | ||
| Tumor size (cm) | ⩽5 | 36 | 12 | 24 | 0.007⁎ |
| >5 | 44 | 28 | 16 | ||
| No. of tumor nodules | 1 | 66 | 22 | 34 | 0.227 |
| ⩾2 | 14 | 8 | 6 | ||
| Cirrhosis | Absent | 18 | 5 | 13 | 0.032⁎ |
| Present | 62 | 35 | 27 | ||
| Venous infiltration | Absent | 49 | 22 | 27 | 0.251 |
| Present | 31 | 18 | 13 | ||
| Edmondson–Steiner grading | I+II | 60 | 28 | 32 | 0.302 |
| III+IV | 20 | 12 | 8 | ||
| TNM tumor stage | I+II | 61 | 25 | 36 | 0.004⁎ |
| III+IV | 19 | 15 | 4 | ||
HCC, hepatocellular carcinoma; HBV, hepatitis B virus; AFP, alpha-fetoprotein; TNM, tumor-node-metastasis.
⁎
Statistically significant.