Optogenetic release of endogenous neuromodulators transforms eligibility traces induced by spaced single ST-conditioning.
Experimental design (left): two pathways received 40 ST-conditioning epoch in an alternated manner every 20 sec. One pathway (red or blue symbols) was paired with 1 s light (10 light pulses (10 ms 700 mA each) delivered at 10 Hz); the unpaired pathway (grey symbols) served as a control.
(A) Light stimulation transforms LTP traces induced by pre-post conditioning (red symbols) in slices from TH-ChR2 mice.
(B) Light stimulation transforms LTD traces induced by post-pre conditioning (blue symbols) in slices from the Tph2-ChR2 mice.
Traces in A and B are coded as in Figure 1. Scale: 2 mV, 25 ms