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. Author manuscript; available in PMC: 2016 Nov 3.
Published in final edited form as: Structure. 2015 Oct 22;23(11):2076–2086. doi: 10.1016/j.str.2015.09.009

Figure 6. TEAD and PDEδ Have a Similar Hydrophobic Central Pocket.

Figure 6

(A) Superposition of TEAD-FA and PDEδ-farnesyl (PDB code 3T5I) complexes. Farnesyl (shown as orange sticks) and FA (shown as pink sticks) occupy the central pocket of PDEδ and TEAD, respectively.

(B) A structural model to show that a fenamate analog (grey sticks) extends from the central pocket to interfere with TEAD-YAP interaction (red circle). A propyne substituent was added ortho to the acid of FA and the compound was docked onto the TEAD1-YAP complex (PDB code 3KYS). Bulky substituents in this position may disrupt YAP binding.