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. 2015 Nov 26;5:85. doi: 10.3389/fcimb.2015.00085

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Copyright © 2015 Josse, Velard and Gangloff.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Staphylococcus aureus interaction with BEM. Staphylococcus aureus can interact with the BEM to concentrate around osteoblasts. Collagen adhesin (Cna) links with type I collagen, bone sialoprotein binding protein (Bbp) links with bone sialoprotein, MHC II analog protein (Map) can potentially link osteopontin. Fibronectin binding proteins A and B (FnBP A/B) link with fibronectin and act as bridges between Staphylococcus aureus and osteoblasts through α5β1 integrin.