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. 2015 Nov 26;5:85. doi: 10.3389/fcimb.2015.00085

Figure 5.

Figure 5

Induction of osteoclastogenesis by Staphylococcus aureus-challenged osteoblasts. S. aureus-challenged osteoblasts increase their expression and production of RANK-L, directly or through the COX-2/PGE2 pathway. It leads to an excessive formation and activation of osteoclasts and to a severe bone resorption in addition to a decreased production of OPG.