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. 2015 Nov 26;5:16777. doi: 10.1038/srep16777

Figure 6. IL-10 signaling is necessary for Leishmania growth induced by PKR activation via Tat.

Figure 6

THP-1 cells were treated with Tat (A) or transfected with Tat86-WT or Tat86-R(49-57)R (B) and then infected with L. amazonensis for 4 h. Total RNA was extracted and analyzed for IL-10 transcripts using quantitative real-time PCR. The infection index was evaluated for THP-1 infected cells treated with neutralizing anti-IL-10 R antibody or the IgG isotype (C) and in THP-1 cells transfected with Tat86-WT or Tat86-R(49-57)R (D). The results are representative of three independent experiments. *P < 0.05.