Figure 6. Missense mutations of HsIMPDH1 linked to retinopathies map into the nucleotide-binding sites.

Blue and green cartoon representations of two interacting Bateman domains of a HsIMPDH1 homology model bound to GDP (red or orange sticks). The side chain of residues whose mutations are linked to RP and LCA are shown in sticks. Key interactions are represented by orange dashes.