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. 2015 Nov 11;10:1–17. doi: 10.1016/j.nicl.2015.10.013

Fig. 2.

Fig. 2

Longitudinal MRI studies within lesions. The first row of the figure shows an axial slice from the multiple MRI sequences, 175 days after baseline (from left to right, the FLAIR, T2, PD, and T1 sequences). In each sequence, a red box shows an area with a lesion that develops during the follow-up period. In the subsequent rows of the figure, we show the longitudinal behavior within this red box. Each column of the figure represents a different MRI study, starting at 98 days after baseline in the far left column and going until 343 days after baseline. A lesion is first identified in this area at 175 days. The first four rows show the longitudinal behavior of the FLAIR, T2, PD, and T1 sequences. The next row shows the segmentation of the edema and lesion tissue. The following row shows the distance to the boundary of abnormal MRI signal. The last row shows the score on the first PC, which identifies areas of lesion repair and permanent damage.