Fig. 3.

Multi-sequence lesion profiles. The first column of the figure shows the full longitudinal profiles from all four sequences (from top to bottom, the FLAIR, T2, PD, and T1 sequences). The profiles are from 150 randomly sampled voxels from the lesion in Fig. 2, and for display purposes the periods between each study have been linearly interpolated. Each line in the plot represents the longitudinal profile from a single voxel. The x-axis shows the time in days from the subject's baseline visit, the time of lesion incidence is denoted by a dashed line, and the y-axis shows the normalized sequence intensities. The second column shows the same voxels after temporal alignment and linear interpolation over the 200 day period after incidence, the time period used in this analysis. The profiles are colored by distance to the boundary of abnormal MRI signal.