Table 1. Relative changes in protein abundance in rat liver in response to repeat acetaminophen exposure.
Timepoint (h) | Doses administered | Proteins increased abundance (p < 0.05) | Proteins decreased abundance (p < 0.05) | Total | Percentage of quantifiable proteome |
---|---|---|---|---|---|
24 | 1 | 30 | 43 | 73 | 6.24 |
48 | 2 | 116 | 199 | 315 | 26.95 |
72 | 3 | 111 | 145 | 256 | 21.90 |
96 | 4 | 86 | 125 | 211 | 18.05 |
The number of proteins that were increased or decreased in abundance in rat liver at each timepoint compared to control animals is indicated. The total number of changed proteins is expressed as a percentage of the total number of proteins quantified in the analysis (1169).