Table 1. Relative changes in protein abundance in rat liver in response to repeat acetaminophen exposure.

Timepoint (h)	Doses administered	Proteins increased abundance (p < 0.05)	Proteins decreased abundance (p < 0.05)	Total	Percentage of quantifiable proteome
24	1	30	43	73	6.24
48	2	116	199	315	26.95
72	3	111	145	256	21.90
96	4	86	125	211	18.05

The number of proteins that were increased or decreased in abundance in rat liver at each timepoint compared to control animals is indicated. The total number of changed proteins is expressed as a percentage of the total number of proteins quantified in the analysis (1169).