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. 2015 Nov 26;5:17172. doi: 10.1038/srep17172

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Copyright © 2015, Macmillan Publishers Limited

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(a) Distribution of PB integration sites on chromosomes. PB broadly targeted all chromosomes, except chromosomes10 and 27. (b) Analysis of integration sites in genes showing that most PB insertions were found in intergenic regions and introns, with only 7.0% appearing in exons. (c) Sequence logo analysis of the nucleotide composition of 20 bp flanking sequences around the insertion site “TTAA” based on 71 PB insertion events. All of the integrations show TTAA target site specificity, and an enrichment of As and Ts in the flanking sequences is observed. However, the nearest five nucleotides upstream and downstream of the integration sites are changed, presenting a novel pattern of nucleotide composition compared with previous reports.