Table 2. Histone residues affected by the H4 tetra-acetylation and their interactions.
| Histone (molecule) | Residue(s) | Neighbor residue involved in interaction | Interaction | DNA/histone (molecule) | Residue/nucleotide | Distance (Å)§ |
|---|---|---|---|---|---|---|
| H3 (A) | F78 | Q76 | Inter-nucleosomal | Chain J | dC–62 | 2.94 |
| H3 (E) | K37–P38 | Inter-nucleosomal | Chain I | dC–5 | 7.36 | |
| H4 (B) | V21–N25, K31–P32 | Inter-nucleosomal | Chain I | dT57 | 6.43 | |
| H4 (F) | H18 | Inter-nucleosomal | H2A (C) | D90 | 3.02 | |
| H4 (F) | G101 | Intra-nucleosomal | H4 (F) | M84 | 3.30 | |
| H2A (C) | K13 | Inter-nucleosomal | Chain I | dC6 | 7.44 | |
| H2A (C) | P117–K118 | Inter-nucleosomal | Chain J | dC34 | 13.08 | |
| H2A (G) | A14–K15 | Inter-nucleosomal | Chain J | dA66 | 14.71 | |
| H2A (G) | A103 | Intra-nucleosomal | H2A (G) | G105 | 3.16 | |
| H2B (D) | S32–E35 | Intra-nucleosomal | Chain I | dG30 | 3.46 | |
| H2B (D) | S32–E35 | Intra-nucleosomal | Chain J | dT50 | 3.34 | |
| H2B (D) | V48‡ | Inter-nucleosomal | H3 (E) | D77‡ | 3.51‡ | |
| H2B (D) | V48 | Inter-nucleosomal | H4 (F) | V21 | 3.37 | |
| H2B (H) | A124 | S123 | Inter-nucleosomal | Chain J | dT67 | 4.51 |
§Distance between the atoms involved in the interaction, or the nearest atoms between the indicated residue(s)/nucleotide.
‡Distance between the main-chain carbonyl O atom of V48 (molecule-D H2B) and the OD1 atom of D77 (molecule-E H3), which forms an inter-nucleosomal interaction in the crystal through Mn++. This inter-surface Mn++ is not significantly affected by the H4-tetra-acetylation.