Table 3.

Association between binge eating in adolescence and genetic variants reliably related to BMI stratified according to sex

Chrom	Position	SNP	Putative gene	Effect allelea	Other allele	RSQR	Females, minimally adjusted model (N = 2,725)		Males, minimally adjusted model (N = 2,191)
							OR (95% CI)b	P value	OR (95% CI)b	P value
1	72585028	rs2815752	NEGR1	A	G	0.996	0.99 (0.86-1.15)	0.92	1.32 (1.00-1.73)	0.047
1	74764232	rs1514175	TNNI3K	A	G	0.998	1.09 (0.94-1.26)	0.24	1.03 (0.79-1.33)	0.83
1	96717385	rs1555543	PTBP2	C	A	0.996	0.99 (0.86-1.14)	0.85	1.14 (0.87-1.49)	0.35
1	176156103	rs543874	SEC16B	G	A	0.997	0.96 (0.80-1.14)	0.60	1.27 (0.95-1.71)	0.12
2	612827	rs2867125	TMEM18	C	T	0.999	1.10 (0.91-1.34)	0.32	1.06 (0.74-1.51)	0.75
2	25011512	rs713586	RBJ/ADCY3/POMC	C	T	0.999	1.02 (0.89-1.18)	0.75	1.00 (0.77-1.30)	0.98
2	59156381	rs887912	FANCL	T	C	0.997	0.96 (0.81-1.12)	0.57	0.86 (0.64-1.15)	0.31
2	142676401	rs2890652	LRP1B	C	T	0.989	1.06 (0.88-1.28)	0.53	0.89 (0.63-1.27)	0.52
3	85966840	rs13078807	CADM2	G	A	0.997	0.96 (0.81-1.15)	0.69	1.08 (0.79-1.48)	0.63
3	187317193	rs9816226	ETV5	T	A	0.956	1.00 (0.83-1.21)	0.96	1.11 (0.77-1.60)	0.56
4	44877284	rs10938397	GNPDA2	G	A	0.988	1.11 (0.96-1.28)	0.17	1.09 (0.83-1.42)	0.53
4	103407732	rs13107325	SLC39A8	T	C	0.997	1.09 (0.83-1.43)	0.55	0.94 (0.57-1.55)	0.79
5	75050998	rs2112347	FLJ35779/HMGCR	T	G	0.995	1.21 (1.04-1.40)	0.012	0.92 (0.70-1.21)	0.55
5	124360002	rs4836133	ZNF608	A	C	0.943	1.07 (0.92-1.23)	0.39	1.11 (0.85 -1.45)	0.45
6	34410847	rs206936	HMGA1	G	A	0.988	1.01 (0.85-1.21)	0.89	0.97 (0.69-1.35)	0.85
6	50911009	rs987237	TFAP2B	G	A	0.999	1.01 (0.84-1.21)	0.93	1.28 (0.93-1.76)	0.14
9	28404339	rs10968576	LRRN6C	G	A	0.999	1.06 (0.91-1.23)	0.48	0.89 (0.67-1.18)	0.40
11	8561169	rs4929949	RPL27A	C	T	0.967	0.93 (0.80-1.07)	0.33	1.06 (0.81-1.38)	0.69
11	27682562	rs10767664	BDNF	A	T	0.997	1.04 (0.87-1.25)	0.64	1.39 (0.98-1.97)	0.056
11	47607569	rs3817334	MTCH2	T	C	0.998	1.01 (0.87-1.16)	0.90	1.05 (0.81-1.36)	0.72
12	48533735	rs7138803	FAIM2	A	G	0.998	1.00 (0.86-1.15)	0.97	0.98 (0.75-1.29)	0.90
13	26918180	rs4771122	MTIF3	G	A	0.931	0.91 (0.77-1.09)	0.30	1.03 (0.75-1.42)	0.84
14	29584863	rs11847697	PRKD1	T	C	0.969	0.93 (0.65-1.33)	0.69	0.72 (0.36-1.44)	0.33
14	79006717	rs10150332	NRXN3	C	T	0.996	0.89 (0.74-1.06)	0.19	0.70 (0.49-1.01)	0.047
15	65873892	rs2241423	MAP2K5	G	A	0.999	1.05 (0.88-1.25)	0.59	0.86 (0.64-1.17)	0.34
16	19841101	rs12444979	GPRC5B	C	T	0.998	1.06 (0.86-1.30)	0.59	1.44 (0.94-2.21)	0.083
16	28793160	rs7359397	SH2B1	T	C	0.999	0.97 (0.84-1.11)	0.63	0.97 (0.74-1.26)	0.81
16	52361075	rs1558902	FTO	A	T	0.997	1.30 (1.13-1.49)	3.3 × 10−4	1.23 (0.92-1.64)	0.51
18	55990749	rs571312	MC4R	A	C	0.999	1.04 (0.88-1.23)	0.62	1.23 (0.92-1.64)	0.17
19	39001372	rs29941	KCTD15	G	A	0.999	0.96 (0.83-1.12)	0.61	0.98 (0.75--1.29)	0.90
19	50894012	rs2287019	QPCTL/GIPR	C	T	0.999	1.05 (0.88-1.26)	0.58	0.81 (0.59-1.12)	0.21
19	52260843	rs3810291	TMEM160	A	G	0.765	1.10 (0.93-1.31)	0.27	0.84 (0.62-1.14)	0.26

^aBMI increaser allele.

^bOne tailed binomial sign test indicated that the direction of allelic association with binge eating did not occur significantly more often in the same direction as the known BMI associations (females P = 0.11; males P = 0.298).

Bold font indicates statistically significant results (P ≤ 0.05).