Figure 1.

Effect of different treatments on blood pressure: (A) Time course of systolic blood pressure (SBP in mmHg) measured using the tail cuff method; (B) Mean arterial blood pressure (MABP in mmHg) on Day 28 measured by invasive carotid artery cannulation. Data expressed as mean ± SEM. N= number of rats **p < 0.01, ***p < 0.001 compared with basal SBP (at week 0) (within the group comparison) using one-way ANOVA followed by Bonferroni as a post-ANOVA test. ap < 0.05, bp < 0.01, cp < 0.001 compared with NORM-CON; αp < 0.05, βp < 0.01, γp < 0.001 compared with L-NAME control (inter-group comparison) using two-way (for SBP) and one way ANOVA (for MABP on Day 28) followed by Bonferroni as a post-ANOVA test