Table III.
Allele frequencies in COPD and control subjects for SNPs.
| SNP | Allele | Control, n (%) | Case, n (%) | χ2 | P-value | OR (95% CI) | P(Bonferroni) | Adjusted P-value | Adjusted OR (95% CI) | Adjusted P(Bonferroni) |
|---|---|---|---|---|---|---|---|---|---|---|
| rs1059823 | G | 139 (33) | 222 (34) | 0.0181 | 0.8929 | 1.01 (0.79–1.32) | 67.8604 | 0.8290 | 0.97 (0.74–1.27) | 63.0040 |
| A | 283 (67) | 440 (66) | ||||||||
| rs1205 | C | 168 (40) | 308 (47) | 5.2168 | 0.0223a | 1.34 (1.04–1.71) | 1.6948 | 0.0030a | 1.48 (1.14–1.91) | 0.2280 |
| T | 252 (60) | 346 (53) | ||||||||
| rs17019336 | A | 136 (32) | 242(37) | 2.1770 | 0.1401 | 1.21 (0.94–1.57) | 10.6476 | 0.0670 | 1.28 (0.98–1.68) | 5.0920 |
| T | 284 (68) | 416 (63) | ||||||||
| rs1799964 | T | 333 (79) | 519 (79) | 0.0008 | 0.9772 | 1.00 (0.74–1.36) | 74.2672 | 0.8140 | 0.96 (0.71–1.31) | 61.8640 |
| C | 87 (21) | 135 (21) | ||||||||
| rs1800610 | T | 71 (17) | 112 (17) | 0.0117 | 0.9137 | 1.02 (0.74–1.41) | 69.4412 | 0.9007 | 0.98 (0.70–1.38) | 68.4532 |
| C | 355 (83) | 550 (83) | ||||||||
| rs2077464 | T | 271 (65) | 420 (66) | 0.1909 | 0.6621 | 1.06 (0.82–1.37) | 50.3196 | 0.8230 | 1.03 (0.79–1.35) | 62.5480 |
| C | 149 (35) | 218 (34) | ||||||||
| rs2236302 | C | 369 (88) | 584 (89) | 0.2011 | 0.6539 | 1.09 (0.75–1.59) | 49.6964 | 0.4140 | 1.18 (0.80–1.75) | 31.4640 |
| G | 51 (12) | 74 (11) | ||||||||
| rs2292566 | A | 125 (30) | 209 (32) | 0.4800 | 0.4884 | 1.10 (0.84–1.43) | 37.1184 | 0.7630 | 1.04 (0.79–1.38) | 57.9880 |
| G | 295 (70) | 449 (68) | ||||||||
| rs2353397 | C | 123 (29) | 382 (58) | 83.3798 | 6.8×10−20a | 3.29 (2.54–4.28) | 5.2×10−18a | <0.0001a | 2.16 (1.66–2.81) | <0.0001a |
| T | 297 (71) | 280 (42) | ||||||||
| rs25882 | T | 147 (35) | 240 (36) | 0.2421 | 0.6227 | 1.07 (0.83–1.38) | 47.3252 | 0.4650 | 1.10 (0.85–1.44) | 35.3400 |
| C | 273 (65) | 418 (64) | ||||||||
| rs2808630 | C | 66 (16) | 119 (18) | 1.0136 | 0.3140 | 1.18 (0.85–1.65) | 23.8640 | 0.2120 | 0.86 (0.69–1.09) | 16.1120 |
| T | 354 (84) | 539 (82) | ||||||||
| rs3749893 | A | 286 (67) | 454 (69) | 0.6232 | 0.4299 | 1.11 (0.86–1.44) | 32.6724 | 0.4510 | 1.11 (0.84–1.46) | 34.2760 |
| G | 140 (33) | 200 (31) | ||||||||
| s4987835 | A | 236 (56) | 382 (60) | 1.7185 | 0.1899 | 1.19 (0.92–1.51) | 14.4324 | 0.2950 | 1.15 (0.88–1.49) | 22.4200 |
| G | 184 (44) | 252 (40) | ||||||||
| rs709932 | A | 73 (17) | 131 (20) | 1.2714 | 0.2595 | 1.20 (0.87–1.65) | 19.7220 | 0.2860 | 1.19 (0.86–1.65) | 21.7360 |
| G | 347 (83) | 519 (80) | ||||||||
| rrs7217852 | A | 273 (65) | 434 (66) | 0.0652 | 0.7985 | 1.03 (0.80–1.34) | 60.6860 | 0.8460 | 1.03 (0.79–1.34) | 64.2960 |
| G | 147 (35) | 226 (34) | ||||||||
| rs7776375 | A | 270 (63) | 438 (66) | 0.8832 | 0.3473 | 1.13 (0.88–1.46) | 26.3948 | 0.2570 | 1.17 (0.89–1.52) | 19.5320 |
| G | 156 (37) | 224 (34) | ||||||||
| rs10069690 | C | 331 (80) | 520 (81) | 0.0264 | 0.8709 | 1.03 (0.75–1.40) | 66.1884 | 0.6480 | 1.08 (0.78–1.48) | 49.2480 |
| T | 81 (20) | 124 (19) | ||||||||
| rs1051740 | T | 247 (60) | 403 (61) | 0.0424 | 0.8369 | 1.03 (0.79–1.32) | 63.6044 | 0.8910 | 1.02 (0.79–1.32) | 67.7160 |
| C | 163 (40) | 259 (39) | ||||||||
| rs11155242 | A | 372 (90) | 604 (91) | 0.5784 | 0.4469 | 1.18 (0.77–1.79) | 33.9644 | 0.2560 | 1.28 (0.83–1.94) | 19.4560 |
| C | 42 (10) | 58 (9) | ||||||||
| rs1295685 | T | 118 (29) | 221 (33) | 2.8124 | 0.0935 | 1.26 (0.96–1.64) | 7.1060 | 0.1730 | 1.21 (0.92–1.60) | 13.1480 |
| C | 296 (71) | 441 (67) | ||||||||
| rs1435867 | C | 55 (13) | 90 (14) | 0.0200 | 0.8877 | 1.03 (0.72–1.47) | 67.4652 | 0.5300 | 0.89 (0.62–1.29) | 40.5080 |
| T | 355 (87) | 566 (86) | ||||||||
| rs16909898 | G | 33 (8) | 54 (8) | 0.0101 | 0.9200 | 1.02 (0.65–1.61) | 69.9200 | 0.3140 | 0.79 (0.50–1.25) | 23.8640 |
| A | 379 (92) | 606 (92) | ||||||||
| rs1881457 | A | 308 (74) | 495 (75) | 0.0726 | 0.7876 | 1.04 (0.78–1.38) | 59.8576 | 0.9120 | 1.02 (0.76–1.36) | 69.3120 |
| C | 108 (26) | 167 (25) | ||||||||
| rs2241718 | T | 114 (28) | 206 (31) | 1.4433 | 0.2296 | 1.18 (0.90–1.55) | 17.4496 | 0.2930 | 1.16 (0.88–1.53) | 22.2680 |
| C | 298 (72) | 456 (69) | ||||||||
| rs2277027 | C | 64 (15) | 106 (16) | 0.0586 | 0.8088 | 1.04 (0.74–1.46) | 61.4688 | 0.8350 | 0.96 (0.68–1.36) | 63.4600 |
| A | 350 (85) | 556 (84) | ||||||||
| rs2736100 | T | 231 (57) | 368 (58) | 0.1539 | 0.6948 | 1.05 (0.82–1.35) | 52.8048 | 0.6340 | 1.06 (0.82–1.38) | 48.1840 |
| G | 173 (43) | 262 (42) | ||||||||
| rs35621 | C | 305 (74) | 499 (75) | 0.1317 | 0.7167 | 1.05 (0.79–1.40) | 54.4692 | 0.3480 | 1.15 (0.86–1.54) | 26.4480 |
| T | 105 (26) | 163 (25) | ||||||||
| rs3995090 | C | 288 (70) | 461 (71) | 0.1521 | 0.6965 | 1.06 (0.80–1.39) | 52.9340 | 0.4200 | 1.12 (0.84–1.48) | 31.9200 |
| A | 122 (30) | 185 (29) | ||||||||
| rs4246742 | A | 244 (60) | 429 (65) | 3.0339 | 0.0815 | 1.25 (0.97–1.61) | 6.1940 | 0.0510 | 1.32 (1.01–1.71) | 3.8760 |
| T | 166 (40) | 233 (35) | ||||||||
| rs6712954 | G | 321 (78) | 545 (82) | 3.1679 | 0.0751 | 1.32 (0.97–1.79) | 5.7076 | 0.0560 | 1.38 (1.01–1.89) | 4.2560 |
| A | 91 (22) | 117 (18) | ||||||||
| rs829259 | A | 137 (33) | 233 (35) | 0.4250 | 0.5145 | 1.09 (0.84–1.41) | 39.1020 | 0.9300 | 1.01 (0.77–1.32) | 70.6800 |
| T | 275 (67) | 429 (65) | ||||||||
| rs10075508 | T | 69 (16) | 108 (17) | 0.0253 | 0.8736 | 1.03 (0.74–1.43) | 66.3936 | 0.9070 | 1.02 (0.72–1.44) | 68.9320 |
| C | 357 (84) | 544 (83) | ||||||||
| rs10512249 | T | 33 (8) | 52 (8) | 0.0606 | 0.8056 | 1.06 (0.67–1.67) | 61.2256 | 0.4950 | 1.16 (0.75–1.80) | 37.6200 |
| C | 383 (92) | 570 (92) | ||||||||
| rs12899618 | G | 370 (89) | 579 (89) | 0.0806 | 0.7765 | 1.06 (0.72–1.56) | 59.0140 | 0.6010 | 1.11 (0.75–1.65) | 45.6760 |
| A | 48 (11) | 71 (11) | ||||||||
| rs13706 | G | 272 (65) | 427 (65) | 0.0598 | 0.8068 | 1.03 (0.80–1.34) | 61.3168 | 0.8300 | 0.97 (0.75–1.27) | 63.0800 |
| A | 148 (35) | 225 (35) | ||||||||
| rs1531697 | A | 255 (61) | 411 (63) | 0.5370 | 0.4637 | 1.10 (0.85–1.41) | 35.2412 | 0.4750 | 1.10 (0.85–1.43) | 36.1000 |
| T | 163 (39) | 239 (37) | ||||||||
| rs1800925 | T | 62 (15) | 105 (17) | 0.8620 | 0.3531 | 1.18 (0.84–1.66) | 26.8356 | 0.1000 | 1.32 (0.94–1.85) | 7.6000 |
| C | 352 (85) | 507 (83) | ||||||||
| rs3024791 | G | 388 (93) | 616 (95) | 1.5299 | 0.2161 | 1.39 (0.82–2.34) | 16.4236 | 0.3820 | 1.25 (0.76–2.06) | 29.0320 |
| A | 28 (7) | 32 (5) | ||||||||
| rs6537302 | A | 310 (75) | 480 (77) | 0.7206 | 0.3959 | 1.13 (0.85–1.51) | 30.0884 | 0.9110 | 1.10 (0.76–1.36) | 69.2360 |
| T | 104 (25) | 142 (23) | ||||||||
| rs6555465 | G | 195 (46) | 310 (48) | 0.4399 | 0.5072 | 1.09 (0.85–1.39) | 38.5472 | 0.5010 | 1.09 (0.85–1.41) | 38.0760 |
| A | 231 (54) | 338 (52) | ||||||||
| rs673400 | C | 178 (43) | 278 (43) | 0.0062 | 0.9371 | 1.01 (0.79–1.30) | 71.2196 | 0.9280 | 0.99 (0.76–1.28) | 70.5280 |
| G | 238 (57) | 368 (57) | ||||||||
| rs6889822 | G | 268 (64) | 417 (65) | 0.0594 | 0.8073 | 1.03 (0.80–1.34) | 61.3548 | 0.5000 | 1.10 (0.84–1.43) | 38.0000 |
| A | 148 (36) | 223 (35) | ||||||||
| rs8004738 | G | 184 (44) | 275 (44) | 0.0092 | 0.9236 | 1.01 (0.79–1.30) | 70.1936 | 0.6650 | 1.01 (0.82–1.37) | 50.5400 |
| A | 232 (56) | 351 (56) | ||||||||
| rs1003349 | G | 238 (57) | 392 (60) | 0.8897 | 0.3456 | 1.13 (0.88–1.45) | 26.2656 | 0.2340 | 1.17 (0.90–1.51) | 17.7840 |
| T | 178 (43) | 260 (40) | ||||||||
| rs1032295 | T | 320 (75) | 523 (80) | 3.1870 | 0.0742 | 1.30 (0.97–1.74) | 5.6392 | 0.1130 | 1.28 (0.94–1.73) | 8.5880 |
| G | 106 (25) | 133 (20) | ||||||||
| rs1042522 | C | 184 (44) | 304 (47) | 0.8170 | 0.3660 | 1.12 (0.88–1.43) | 27.8160 | 0.4090 | 1.11 (0.86–1.44) | 31.0840 |
| G | 236 (56) | 348 (53) | ||||||||
| rs1052443 | C | 281 (67) | 457 (71) | 1.7602 | 0.1846 | 1.20 (0.92–1.56) | 14.0296 | 0.1610 | 1.22 (0.93–1.60) | 12.2360 |
| A | 139 (33) | 189 (29) | ||||||||
| rs12504628 | T | 305 (72) | 475 (72) | 0.0847 | 0.7710 | 1.04 (0.79–1.37) | 58.5960 | 0.9810 | 1.04 (0.76–1.33) | 74.5560 |
| C | 121 (28) | 181 (28) | ||||||||
| rs1695 | G | 72 (17) | 126 (19) | 0.6673 | 0.4140 | 1.14 (0.83–1.57) | 31.4640 | 0.4650 | 1.13 (0.82–1.57) | 35.3400 |
| A | 346 (83) | 530 (81) | ||||||||
| rs1800469 | C | 182 (44) | 315 (48) | 2.1252 | 0.1449 | 1.20 (0.94–1.54) | 11.0124 | 0.2010 | 1.74 (1.35–2.27) | 15.2760 |
| T | 234 (56) | 337 (52) | ||||||||
| rs20541 | T | 118 (28) | 228 (35) | 5.3633 | 0.0206a | 1.37 (1.05–1.79) | 1.5656 | 0.0280a | 1.36 (1.04–1.80) | 2.1280 |
| C | 302 (72) | 426 (65) | ||||||||
| rs2070600 | G | 312 (73) | 529 (81) | 8.1712 | 0.0043a | 1.52 (1.14–2.03) | 0.3268 | 0.0130a | 1.47 (1.08–1.98) | 0.9880 |
| A | 114 (27) | 127 (19) | ||||||||
| rs2853209 | A | 191 (45) | 305 (47) | 0.1953 | 0.6586 | 1.06 (0.83–1.35) | 50.0536 | 0.9890 | 0.10 (0.77–1.29) | 75.1640 |
| T | 231 (55) | 349 (53) | ||||||||
| rs4073 | A | 185 (44) | 300 (46) | 0.5198 | 0.4709 | 1.10 (0.86–1.40) | 35.7884 | 0.2530 | 1.16 (0.90–1.50) | 19.2280 |
| T | 235 (56) | 348 (54) | ||||||||
| rs6937121 | T | 254 (60) | 423 (65) | 2.1263 | 0.1448 | 1.21 (0.94–1.56) | 11.0048 | 0.1720 | 1.20 (0.92–1.56) | 13.0720 |
| G | 166 (40) | 229 (35) | ||||||||
| rs6957 | G | 150 (36) | 241 (37) | 0.0802 | 0.7771 | 1.04 (0.80–1.34) | 59.0596 | 0.6830 | 1.06 (0.81–1.38) | 51.9080 |
| A | 268 (64) | 415 (63) | ||||||||
| rs1051730 | C | 403 (97) | 641 (97) | 0.2343 | 0.6284 | 1.20 (0.57–2.52) | 47.3252 | 0.6480 | 1.17 (0.60–2.29) | 49.2480 |
| T | 11 (3) | 21 (3) | ||||||||
| rs10947233 | G | 299 (72) | 526 (79) | 7.4524 | 0.0063a | 1.49 (1.12–1.98) | 0.4788 | 0.0060a | 1.51 (1.12–2.03) | 0.4560 |
| T | 115 (28) | 136 (21) | ||||||||
| rs11106030 | C | 355 (85) | 560 (85) | 0.0013 | 0.9716 | 1.01 (0.71–1.42) | 73.8416 | 0.7030 | 1.07 (0.75–1.52) | 53.4280 |
| A | 63 (15) | 100 (15) | ||||||||
| rs1130864 | T | 23 (6) | 43 (7) | 0.6081 | 0.4355 | 1.23 (0.73–2.07) | 33.0980 | 0.3890 | 1.24 (0.77–2.00) | 29.5640 |
| C | 389 (94) | 591 (93) | ||||||||
| rs1800629 | G | 379 (90) | 627 (95) | 7.8793 | 0.0050a | 1.94 (1.21–3.10) | 0.3800 | 0.0060a | 1.97 (1.21–3.21) | 0.4560 |
| A | 41 (10) | 35 (5) | ||||||||
| rs2241712 | A | 188 (45) | 342 (52) | 3.9820 | 0.0460a | 1.28 (1.00–1.64) | 3.4960 | 0.0498a | 1.24 (0.96–1.59) | 3.7848 |
| G | 226 (55) | 320 (48) | ||||||||
| rs2280090 | G | 395 (94) | 629 (95) | 0.9844 | 0.3211 | 1.30 (0.77–2.20) | 24.4036 | 0.4640 | 1.22 (0.72–2.06) | 35.2640 |
| A | 27 (6) | 33 (5) | ||||||||
| rs2395730 | A | 119 (28) | 209 (32) | 1.3886 | 0.2386 | 1.17 (0.90–1.54) | 18.1336 | 0.0850 | 1.28 (0.97–1.69) | 6.4600 |
| C | 303 (72) | 453 (68) | ||||||||
| rs2736118 | A | 397 (94) | 630 (95) | 0.6150 | 0.4329 | 1.24 (0.72–2.12) | 32.9004 | 0.2850 | 1.36 (0.78–2.37) | 21.6600 |
| G | 25 (6) | 32 (5) | ||||||||
| rs2736122 | C | 388 (94) | 632 (95) | 1.5783 | 0.2090 | 1.41 (0.82–2.42) | 15.8840 | 0.0510 | 1.77 (1.02–3.07) | 3.8760 |
| T | 26 (6) | 30 (5) | ||||||||
| rs3817928 | A | 370 (89) | 596 (90) | 0.1202 | 0.7288 | 1.07 (0.72–1.61) | 55.3888 | 0.4410 | 1.17 (0.78–1.76) | 33.5160 |
| G | 44 (11) | 66 (10) | ||||||||
| rs584367 | T | 91 (22) | 152 (23) | 0.1399 | 0.7083 | 1.06 (0.79–1.42) | 53.8308 | 0.8590 | 1.03 (0.76–1.39) | 65.2840 |
| C | 323 (78) | 510 (77) | ||||||||
| rs1042714 | C | 374 (90) | 607 (92) | 1.1947 | 0.2744 | 1.27 (0.83–1.96) | 20.8544 | 0.1440 | 1.39 (0.90–2.14) | 10.9440 |
| G | 40 (10) | 374 (90) | ||||||||
| rs13147758 | A | 283 (69) | 464 (71) | 0.8780 | 0.3487 | 1.14 (0.87–1.49) | 26.5012 | 0.3840 | 1.13 (0.86–1.49) | 29.1840 |
| G | 129 (31) | 186 (29) | ||||||||
| rs1422795 | G | 61 (15) | 108 (16) | 0.5395 | 0.4626 | 1.14 (0.81–1.60) | 35.1576 | 0.8690 | 1.03 (0.73–1.46) | 66.0440 |
| A | 353 (85) | 550 (84) | ||||||||
| rs1800796 | C | 293 (71) | 473 (72) | 0.1539 | 0.6948 | 1.06 (0.80–1.39) | 52.8048 | 0.8250 | 1.03 (0.78–1.36) | 62.7000 |
| G | 121 (29) | 185 (28) | ||||||||
| rs2236307 | C | 169 (41) | 286 (43) | 0.7270 | 0.3938 | 1.11 (0.87–1.43) | 29.9288 | 0.4150 | 1.11 (0.86–1.44) | 31.5400 |
| T | 245 (59) | 372 (57) | ||||||||
| rs2280091 | A | 383 (93) | 611 (93) | 0.1518 | 0.6968 | 1.10 (0.68–1.77) | 52.9568 | 0.5020 | 1.17 (0.74–1.87) | 38.1520 |
| G | 31 (7) | 45 (7) | ||||||||
| rs2853676 | G | 335 (81) | 544 (83) | 0.4538 | 0.5005 | 1.12 (0.81–1.54) | 38.0380 | 0.2770 | 1.20 (0.86–1.67) | 21.0520 |
| A | 77 (19) | 112 (17) | ||||||||
| rs868966 | A | 205 (50) | 337 (51) | 0.2934 | 0.5880 | 1.07 (0.84–1.37) | 44.6880 | 0.7890 | 1.04 (0.80–1.34) | 59.9640 |
| G | 209 (50) | 321 (49) | ||||||||
a
P<0.05, significant difference is for the alleles between COPD and controls. χ2 test and logistic analysis were used. Logistic analysis was adjusted by potential confounders, including age, gender and smoking history. COPD, chronic obstructive pulmonary disease; OR, odds ratio; CI, confidence interval.