Table 3.
Association between lipid parameters and prevalent low-grade albuminuria, increased urinary albumin excretion and CKD
| 1-Quartile change of lipid parametersa | |||||
|---|---|---|---|---|---|
| Model 1 | Model 2 | Model 3 | Model 4 | ||
| Low-grade albuminuria | TG | 1.10 (1.06–1.15) | 1.10 (1.06–1.15) | 1.01 (0.96–1.06) | 1.01 (0.97–1.06) |
| TC | 1.06 (1.02–1.11) | 1.03 (0.98–1.07) | 1.01 (0.96–1.05) | 1.02 (0.97–1.06) | |
| HDL-C | 1.00 (0.96–1.05) | 1.05 (1.01–1.10) | 0.99 (0.95–1.04) | 0.99 (0.94–1.04) | |
| LDL-C | 1.02 (0.98–1.07) | 0.99 (0.95–1.04) | 0.97 (0.93–1.02) | 0.98 (0.94–1.03) | |
| Non-HDL-C | 1.07 (1.03–1.12) | 1.05 (1.00–1.09) | 1.00 (0.96–1.05) | 1.01 (0.96–1.06) | |
| Non-HDL-C/HDL-C | 1.08 (1.04–1.13) | 1.10 (1.05–1.15) | 1.01 (0.96–1.06) | 1.01 (0.96–1.07) | |
| TG/HDL-C | 1.08 (1.03–1.12) | 1.09 (1.05–1.14) | 0.99 (0.94–1.04) | 0.99 (0.94–1.04) | |
| Increased urinary albumin excretion | TG | 1.36 (1.27–1.47) | 1.34 (1.24–1.44) | 1.16 (1.07–1.26) | 1.17 (1.08–1.27) |
| TC | 1.03 (0.96–1.11) | 1.01 (0.94–1.08) | 0.95 (0.88–1.02) | 0.96 (0.89–1.04) | |
| HDL-C | 1.25 (1.16–1.35) | 1.26 (1.17–1.36) | 1.17 (1.08–1.27) | 1.16 (1.07–1.26) | |
| LDL-C | 1.04 (0.97–1.12) | 1.02 (0.95–1.09) | 0.96 (0.89–1.04) | 0.98 (0.91–1.06) | |
| Non-HDL-C | 1.12 (1.04–1.20) | 1.09 (1.01–1.17) | 0.99 (0.91–1.07) | 1.00 (0.93–1.08) | |
| Non-HDL-C/HDL-C | 1.28 (1.19–1.38) | 1.25 (1.16–1.35) | 1.09 (1.00–1.18) | 1.10 (1.01–1.19) | |
| TG/HDL-C | 1.42 (1.32–1.53) | 1.40 (1.30–1.51) | 1.21 (1.11–1.31) | 1.21 (1.11–1.31) | |
| CKD | TG | 1.38 (1.29–1.48) | 1.35 (1.25–1.45) | 1.18 (1.09–1.28) | 1.19 (1.10–1.28) |
| TC | 1.05 (0.98–1.13) | 1.03 (0.96–1.10) | 0.97 (0.90–1.05) | 0.99 (0.92–1.07) | |
| HDL-C | 1.25 (1.16–1.34) | 1.25 (1.16–1.34) | 1.16 (1.07–1.25) | 1.15 (1.06–1.24) | |
| LDL-C | 1.05 (0.98–1.13) | 1.03 (0.96–1.10) | 0.98 (0.91–1.05) | 0.99 (0.92–1.07) | |
| Non-HDL-C | 1.15 (1.07–1.23) | 1.11 (1.04–1.20) | 1.02 (0.94–1.10) | 1.03 (0.96–1.11) | |
| Non-HDL-C/HDL-C | 1.32 (1.23–1.41) | 1.28 (1.19–1.37) | 1.11 (1.03–1.20) | 1.12 (1.04–1.22) | |
| TG/HDL-C | 1.42 (1.32–1.53) | 1.39 (1.30–1.50) | 1.21 (1.11–1.31) | 1.21 (1.11–1.31) | |
Data are odds ratios (95% confidence interval). Participants without low-grade albuminuria, increased urinary albumin excretion or CKD are defined as 0 and with low-grade albuminuria, increased urinary albumin excretion or CKD as 1
Model 1 is unadjusted
Model 2 is adjusted for age and sex
Model 3 is further adjusted for BMI, current smoking and drinking status, physical activity level, SBP and HbA1c
Model 4 is further adjusted for previously diagnosed diabetes, cardiovascular diseases, hypertension and dyslipidemia
aAll variables were calculated for 1-Quartile increasing of lipid parameters except for HDL-C, which was calculated for 1-Quartile decreasing