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. 2015 Oct;10(10):1578–1580. doi: 10.4103/1673-5374.165228

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Copyright: © Neural Regeneration Research

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 3.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as the author is credited and the new creations are licensed under the identical terms.

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Transforming growth factor β1 (TGFβ1) is predominantly expressed in neurons in the midbrain.

50 μm vibratome sections from 12-week-old male C57BL/6 mice have been used for free-floating immunohistochemistry. (A) Overview image displaying the localization of substantia nigra pars compacta (SNpc), substantia nigra pars reticularis (SNpr) and nucleus ruber in the ventral midbrain. Rectangle marks the area displayed at high magnification images. Lines represent borders of SNpr, SNpc and nucleus ruber, respectively. Scale bar: 75 μm. (B) Microglia (Iba1⁺), as indicated by white arrows, show no TGFβ1 expression, whereas neurons (indicated by white asterisks) display a strong cytoplasmic immunoreactivity for TGFβ1. Single channel images for Iba1⁺ microglia (C) and TGFβ1 (D) confirm that neurons and not microglia are the primary source of TGFβ1 in the midbrain. Scale bars: 25 μm for B–D.