Fig. 8.

Integrated use of clinical and transcriptomic markers assessed by decision tree cross-validation (10-fold cross-validation; decision trees/candidates were selected upon high specificity). a Decision tree for the incidence of nosocomial infections after trauma under consideration of all time points of the observation period (n = 413 samples). b Assessment of the risk for the development of sepsis during the further course using samples from day 1 after trauma (n = 77 samples). c Decision tree for sepsis under inclusion of all time points of the observation period (n = 502 samples). Threshold levels (ΔCt of gene expression or leukocyte/thrombocyte counts) for the decision of which path is taken are provided in the figures at the corresponding levels. C5 complement component C5, HP haptoglobin, Lc leukocytes, Tc thrombocytes