Figure 8.
Organ biodistribution of curcumin in vivo by HPLC-FLd. Mice were i.v injected with curcumin-loaded NCs at a dose of 16 mg kg−1. A) Representative chromatograms of extracted curcumin from liver and tumor tissues after 1 and 24 h. Highlighted area shows curcumin peaks at retention times of 21.2, 21.8, and 22.5 min. B) Major organ biodistribution profile values for curcumin extracted from liver, lung, tumor (inset), heart, kidneys, and spleen at 1, 4, and 24 h post-injection, expressed as percentage injected dose per gram tissues (% ID/g). Curcumin uptake in tumors was observed at 1 h post-injection and was enhanced after 24 h. Results are expressed as means ± SD (n = 3).