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. 2015 Jul 3;11(36):4704–4722. doi: 10.1002/smll.201403799

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© 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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CT26 tumor growth delay in Balb/c after multiple injections of curcumin-loaded NC via tail vein. Mice were inoculated subcutaneously with 1 × 10⁶ CT26 cells. Animals were then randomly divided into four groups: Control (♦), empty NC (▪), curcumin-loaded NC (), and DOX (positive control) (○). Mice were injected i.v. a total of 4 injections on day 11, 15, 19, and 24 post-tumor inoculation, at drug dose of 16 mg kg⁻¹ curcumin (containing 250 mg polymer per kg) or 5 mg kg⁻¹ DOX. Tumor size measurement was carried out three times a week. Data are given as mean value ± SEM (n = 10). Significant differences were examined using one-way ANOVA following by Tukey's multiple comparison test. *p < 0.05.

Inline graphic — CT26 tumor growth delay in Balb/c after multiple injections of curcumin-loaded NC via tail vein. Mice were inoculated subcutaneously with 1 × 10⁶ CT26 cells. Animals were then randomly divided into four groups: Control (♦), empty NC (▪), curcumin-loaded NC (), and DOX (positive control) (○). Mice were injected i.v. a total of 4 injections on day 11, 15, 19, and 24 post-tumor inoculation, at drug dose of 16 mg kg⁻¹ curcumin (containing 250 mg polymer per kg) or 5 mg kg⁻¹ DOX. Tumor size measurement was carried out three times a week. Data are given as mean value ± SEM (n = 10). Significant differences were examined using one-way ANOVA following by Tukey's multiple comparison test. *p < 0.05.