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. 2015 Jul 3;11(36):4704–4722. doi: 10.1002/smll.201403799

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© 2015 The Authors. Published by WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Scheme 2 — Preparation of curcumin-loaded NC by nanoprecipitation method. Schematic representation of the formulation method of the oil-cored NC. The organic phase composed of polymer, oil, lipophilic surfactant, and the drug dissolved in a water-miscible solvent is added dropwise to an aqueous phase containing a hydrophilic surfactant. Formation of NC takes place by solvent diffusion and polymer precipitation. Finally, the solvent is removed forming NC aqueous dispersion. The average diameter of NC is 160 nm.