Table 3.
Association of the 2 top independent SNPs in COL11A1 and the top SNP in VEGF with hip OA*
| GWAS meta-analysis |
Extension study |
GWAS meta-analysis plus extension study |
||||
|---|---|---|---|---|---|---|
| Gene, SNP, sex | ORM-H(95% CI) | P | ORM-H(95% CI) | P | OR (95% CI) | P |
| COL11A1 | ||||||
| rs1241164 | ||||||
| All | 0.82 (0.74–0.89) | 1.47 × 10−5 | 0.85 (0.68–1.06) | 0.15 | 0.82 (0.75–0.89) | 5.3 ×10−6 |
| Female | 0.79 (0.7–0.89) | 1.27 × 10−4 | 0.96 (0.70–1.32) | 0.81 | 0.81 (0.72–0.91) | 2.4 × 10−4 |
| Male | 0.84 (0.74–0.97) | 0.012 | 0.77 (0.56–1.06) | 0.11 | 0.83 (0.73–0.94) | 3.7 × 10−3 |
| rs4907986 | ||||||
| All | 1.12 (1.06–1.17) | 1.29 × 10−5 | 0.98 (0.85–1.12) | 0.77 | 1.09 (1.05–1.15) | 5.8 × 10−5 |
| Female | 1.13 (1.07–1.21) | 1.05 × 10−4 | 1.15 (0.95–1.39) | 0.13 | 1.13 (1.07–1.21) | 3.2 × 10−5 |
| Male | 1.1 (1.03–1.19) | 0.0069 | 0.95 (0.77–1.18) | 0.67 | 1.08 (1.01–1.16) | 0.015 |
| VEGF | ||||||
| rs833058 | ||||||
| All | 0.92 (0.88–0.97) | 0.0022 | 0.92 (0.85–0.99) | 0.03 | 0.92 (0.88–0.96) | 1.9 × 10−4 |
| Female | 0.99 (0.93–1.06) | 0.75 | 0.91 (0.81–1.01) | 0.07 | 0.97 (0.91–1.02) | 0.21 |
| Male | 0.85 (0.79–0.91) | 1.3 × 10−5 | 0.94 (0.84–1.06) | 0.31 | 0.87 (0.82–0.93) | 2.6 × 10−5 |
*
Single-nucleotide polymorphisms (SNPs) rs1241164 and rs4907986 were genotyped only in samples from Spain and Greece. The odds ratios (ORs) and 95% confidence intervals (95% CIs) are relative to the first listed allele for each SNP in Table 2. OA = osteoarthritis; GWAS = genome-wide association study; ORM-H = OR as determined using the Mantel-Haenszel approach. No significant heterogeneity (P < 0.05) was detected in any of the combined analyses.