Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Optimisation of TiF4/3HF·Et3N mediated hydrofluorination.
 | |||||||
| Entry | TiF4 (equiv) |
3HF·TEA (equiv) |
Time | Temp. | Solvent | Conversion | Yield |
| 1 | 1.5 | 3.0 | 5 h | 0 °C to rt | DCM | 39% | – |
| 2 | 1.5 | 3.0 | 16 h | 0 °C to rt | DCM | >90% | 42% |
| 3 | 0.5 | 3.0 | 16 h | 0 °C to rt | DCM | – | – |
| 4 | 1.5 | 3.0 | 16 h | 0 °C to rt or reflux | THF | – | – |
| 5 | 1.5 | 3.0 | 16 h | 0 °C to rt, then reflux | DCE | 10% | – |
