Figure 1. Administration of 1-[[2-(dimethylamino) ethyl] amino]-4-(hydroxymethyl)-7-[[(4-methylphenyl) sulfonyl] oxy]-9H-xanthone 9 (XNT) increased angiotensin converting enzyme 2 (ACE2) expression in retinas of hyperglycemic rats. A, Representative photomicrographs of retinas of control rats (CTRL), hyperglycemic untreated rats (HG), and hyperglycemic treated rats (HG+XNT). RGC: retinal ganglion cells. B, Quantification of ACE2 expression in retinas of rats. *P<0.05 compared to CTRL and HG groups (one-way ANOVA followed by the Newman-Keuls test).