Figure 4.

Effect of saline (sal) or SKF81297 (0.025 and 0.05 μg/side) infused into the prelimbic cortex before the sample phase on novel object recognition after a retention delay of 10 min. (A) Timeline of experiment 4 to illustrate the 10 min retention delay between the sample and the choice phase, the timing of the infusions 15 min before the choice phase and the repeated (×3) testing in the within-subjects design. (B) Effect of SKF81297 on the first min of exploration of a novel (Nov) and a familiar (Fam) object during the choice phase. *p<0.05, **p<0.001, significant difference as compared to the familiar object. (C) Choice performance presented as discrimination ratio; stippled line indicates chance. *p<0.01, significantly different from the saline group; ^#p<0.05, significantly different from chance. Data are shown as a mean±S.E.M (n=10 rats in total).