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Effect of systemic injections of SKF81297 on spontaneous activity. The rats were habituated to the activity chambers for 30 min before being injected with saline, SKF81297 0.4 or 0.8 mg/kg of SKF81297. Locomotor activity was then monitored for an additional 60 min. Data are presented as mean±S.E.M. (n=12 rats per group). Asterisks indicate a significant difference as compared to saline with **p<0.001, ***p<0.0001.
