Table 1.
Effect of systemic injection or mPFC microinfusion of SKF81297 on exploration time in seconds (mean+S.E.M.) of both objects, during the sample (a), and choice (b) phases of a NOR task.
| Injections | Delay | Sal | 0.4 mg/kg | 0.8 mg/kg |
|---|---|---|---|---|
| Systemic before encoding | 10 min | a | ||
| 70.1±7.3 | 36.2±4.8 ⁎⁎ | 24.8±5.2⁎⁎⁎ | ||
| b | ||||
| 43.6±3.3 | 33.5±5.0 | 24.0±3.1⁎ | ||
| Systemic before encoding | 24 h | a | ||
| 37.6±5.5 | 20.6±4.8⁎ | 18.6±3.4⁎ | ||
| b | ||||
| 30.6±2.2 | 26.5±3.4 | 26.7±2.5 | ||
| Systemic before test session1 | 24 h | a | ||
| 26.6±7.7 | 23.2±1.7 | 29.5±5.1 | ||
| b | ||||
| 24.2±3.1 | 7.5±1.6⁎⁎⁎ | 7.2±1.4 ⁎⁎⁎ | ||
| Infusions | Delay | Sal | 0.025 µg/side | 0.05 µg/side |
| In mPFC before encoding | 10 min | a | ||
| 56.3±4.1 | 45.0±5.2 | 56.1±8.4 | ||
| b | ||||
| 40.4±4.3 | 25.4±3.9⁎ | 33.4±4.6 | ||
⁎
p<0.05;
⁎⁎
p<0.001;
⁎⁎⁎
p<0.0001:significant decreases in the time spent exploring the objects compared to saline (sal).
1
Note: where drug administration was systemic before test session the sample exploration times of the untreated rats are provided by drug condition-to-be, for comparison.