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The schematic summarizes findings in the current study, including 1) the suppression of NF-κB activation stimulated by extracellular (TLR1/2 and 4) and intracellular (TLR9) receptors; 2) inhibitory and stimulatory effects of RTD-1 on LPS-stimulated pathways; and 3) negative regulatory pathways mediated by pAkt identified previously [31].
