FIGURE 3.

The percentage of CD4⁺ and CD8⁺ T cells producing cytokines in HLA-A02.01/HLA-DR1 transgenic mice injected with phosphate-buffered saline (PBS) or recPRAME+AS15 at 2 weeks after the fourth injection. Data are expressed as the pool of 5 mice per group. Percentages of CD4⁺ and CD8⁺ in the PBS group: 0.01 and 0.20, respectively; CD4⁺ and CD8⁺ in the recPRAME+AS15 group: 0.35 and 1.45, respectively. PBS indicates mice injected with PBS; recPRAME+AS15, mice injected with recPRAME formulated with the AS15 immunostimulant. Each bar represents a pool of 5 mice.