Patient 3’s response. A, The primary lesion is a nonpigmented papule on the posterior right lower leg, surrounded by a cluster of pink papules in the posterior medial leg. B, Following 2 intralesional Bacillus Calmette-Guérin (ILBCG) injections in the posterior leg, injected lesions faded in color from black to gray and decreased in size and elevation, whereas uninjected lesions in the pretibial, medial lower, and posterior lower calf faded in color from black to gray and decreased in size and elevation. C, Six months from the first sensitization, there was a complete clinical response at the injected sites. A subcutaneous nodule was found beneath the prior biopsy site on the right posterior calf that had not been treated with ILBCG (not shown).