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. Author manuscript; available in PMC: 2016 Apr 1.
Published in final edited form as: Can J Anaesth. 2015 Feb 14;62(4):345–355. doi: 10.1007/s12630-014-0305-8

Anesthetic drugs, equivalence drugs, equivalence factors, and dose limits

Drug Equivalence
Drug
Equivalence
Factor*
Upper Dose
Limit (mg)
Midazolam Midazolam 1 100
Morphine Morphine 1 200
Fentanyl Morphine 100 20
Hydromorphone Morphine 5 20
Methadone Morphine 0.125 100
Sufentanil Morphine 1000 10
Meperidine Morphine 0.1 300
Propofol Propofol 1 6,200
Etomidate Propofol 5.6 50
Thiopental Propofol 0.5 2,000
Vecuronium Vecuronium 1 50
Atracurium Vecuronium 0.248 500
Pancuronium Vecuronium 0.814 50
Rocuronium Vecuronium 0.190 250
*

Equivalence factor is the factor by which the Drug (column 1) is multiplied to convert it to a comparable dose of the Equivalence Drug (column 2).

Limit of the Drug dose (mg) (values beyond were excluded)