. Author manuscript; available in PMC: 2016 Nov 1.

Published in final edited form as: J Pediatr. 2015 Aug 20;167(5):994–1000.e2. doi: 10.1016/j.jpeds.2015.07.050

Table 2.

Description of AEs during or shortly after ROP study visits (n=65 AEs)

AEs during ROP evaluation (n=59)	n events (%)
Apnea, bradycardia, and/or hypoxia	42	(71%)

Tachycardia	9	(15%)

Emesis	5	(8%)

Epistaxis	1	(2%)

Arrhythmia (bradycardia)	1	(2%)

Retinal Hemorrhage	1	(2%)

AEs after ROP evaluations (n=6)	*n events (%) and associated clinical circumstances*

Apnea, bradycardia, & hypoxia events	4	(67%)
Required bag mask positive pressure ventilation & increased respiratory support		1 due to water droplets from CPAP device, resolved
		2 due to opiates & ROP laser surgery, resolved with intubation
		1 due to GBS sepsis, resolved with intubation and antibiotics

Feeding intolerance	1	(17%)
Required IV fluids and antibiotics		Infant with emesis & abdominal distention. Stopped feeds, started antibiotics, symptoms resolved. Resumed full enteral feeds within 24 hours. No evidence NEC.

Respiratory insufficiency	1	(17%)
Required increased mode of respiratory support		Increased respiratory distress that resolved with change in respiratory support from nasal cannula to CPAP due to chronic lung disease and recent weaning off CPAP.