Table 1.
Demographic and Clinical Characteristics of Children with Optic Pathway Gliomas Experiencing New Onset Vision Loss or Stable Vision.
| New Vision Loss (N= 10) |
Stable Vision (N = 45) |
|
|---|---|---|
| Age, yrs (mean/median) | 6.9/5.8 | 6.5/5.5 |
| Range | (1.1 – 17.8) | (1.2 – 17.1) |
| Female sex, n (%) | 5 (50) | 30 (67) |
| Race, n (%) | ||
| White/Caucasian | 9 (90) | 34 (76) |
| Black/African American | 1 (10) | 6 (13) |
| Multiracial | 0 | 5 (11) |
| Ethnicity, n (%) | ||
| Non-Hispanic | 10 (100) | 42 (93) |
| Hispanic | 0 (0) | 3 (7) |
| Diagnosis, n (%) | ||
| NF1 – Optic Pathway Glioma | 2 (20) | 29 (64) |
| Sporadic – Optic Pathway Glioma | 8 (80) | 16 (36) |
| Treatment of Optic Pathway Glioma, n (%) | ||
| Never | 1 (10) | 18 (40) |
| During Study | 9 (90) | 17 (38) |
| Past | 0 (0) | 10 (22) |
| Total Visits, n (mean/median) | 67 (6.2/5) | 183 (4.0/4) |
| Range | (3 – 12) | (3 – 9) |
| Duration of Enrollment, months (mean/median) | 16.5/15.6 | 13.4/13.4 |
| Range | (6.1 – 34.1) | (5.7 – 23.7) |
| Abnormal Vision Prior to Study Entry, n (%) | 5 (50) | 13 (29) |
| Vision Loss Events During Studya | – | |
| Time to Event, months (mean/median) | 6.3/4.7 | |
| Range | (3.0 – 14.1) | – |
| Visual acuity, n (%) | 7 (39) | – |
| Visual field, n (%) | 8 (44) | – |
| Both visual acuity/field, n (%) | 3 (17) | – |
a
18 events of vision loss experienced during the study.
NF1 = Neurofibromatosis type 1.