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. Author manuscript; available in PMC: 2016 Dec 1.
Published in final edited form as: Trends Biochem Sci. 2015 Oct 21;40(12):765–778. doi: 10.1016/j.tibs.2015.09.003

Figure 2. The IFT building blocks.

Figure 2

IFT-A and IFT-B proteins will assemble into IFT-A and IFT-B subcomplexes; the proteins are believed to be represented in equimolar amounts in each complex. IFT complexes assemble into IFT particles and IFT particles associate with the IFT motors into IFT trains. The BBSome, consisting of at least 7 BBS proteins and BBIP10, appears to be a substoichiometric component of the IFT trains. Peptide coverage in the proteome of whole C. reinhardtii cilia suggests a 10:5:1 ratio for IFT-B/IFT motors, IFT-A, and BBSomes, respectively [2, 22]. Anterograde IFT trains are moved by kinesin-2, which is thought to be associated to IFT-B. IFT dynein is moved as a cargo on anterograde IFT trains to the ciliary tip. Retrograde IFT trains are powered by IFT dynein. How IFT dynein, here depicted as being associated with IFT-A, binds to IFT trains is currently unknown.