Table 1.
MS n = 57 |
Control n = 17 |
pa | |
---|---|---|---|
| |||
Demographics | |||
Sex (% male) | 18 (31.5) | 4 (23.5) | – |
Age (years) | 44.6 (8.4) | 42.7 (10.1) | 0.449 |
Education (years) | 15.1 (2.4) | 15.6 (1.5) | 0.454 |
Disease characteristics | |||
MSFC | 0.15 (0.64) | 0.73 (0.24) | 4×10−4 |
Median EDSS (range) | 2.5 (1–6.5) | – | – |
Median disease duration | 11 (1–33) | – | – |
Behavioral measures | |||
CVLT | 46.7 (11.2) | 57.7 (9.4) | 4×10−4 |
BVMT | 45.9 (13.3) | 56.6 (7.9) | 0.002 |
SDMT | 51.5 (13.6) | 67.4 (11.6) | 1×10−4 |
PASAT | 45.6 (12.3) | 53.5 (6.2) | 0.019 |
Volumetric measures | |||
WM voxels, scaled | 651,875 (55,528) | 692,857 (41,212) | 0.0063 |
GM voxels, scaled | 759,762 (42,178) | 804,744 (39,493) | 2×10−4 |
P-values for behavioral measures are based on demographically-corrected scores (see text for details);
P-values for unpaired Student’s t-tests, all values survive FDR correction;
BVMT=Brief Visuospatial Memory Test-Revised; CVLT=California Verbal Learning Test-II; PASAT=Paced Auditory Serial Addition Test; SDMT=Symbol Digit Modalities Test; WM=white matter; GM=grey matter.