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Schematic summary of reporter assay results. Arrows indicate direction of change in relation to wild type ERβ. In grey are highlighted the instances of differences between each mutant compared to wild type ERβ.
| ERE (DNA binding) | AP1 (Prot-Prot interaction) | |||
|---|---|---|---|---|
| constitutive | E2 dependent | constitutive | E2 dependent | |
| wtERβ | ↑ | ↑↑ | ↓ | ↓↓ |
| S87A | ↑ | ↑↑↑ | – | ↓↓ |
| S87E | ↑ | ↑↑ | – | ↓↓ |
| S105A | ↑ | ↑↑ | – | ↓↓ |
| S105E | ↑↑ | ↑↑↑ | – | ↓ |
