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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Mol Psychiatry. 2015 May 26;21(3):386–393. doi: 10.1038/mp.2015.61

Figure 3. Time line for D-serine treatment and summary of results.

Figure 3

We have previously published that Pick1 knockout mice have reduced D-serine levels at P7 (neonatal stage), but not in adulthood (P56) (Hikida 2008). Based on those results, here we tested whether supplementation of D-serine during the neonatal period (P3–P17) would improve behavioral and electrophysiological deficits seen in adulthood and indeed it did. As a control experiment we also treated the mice with D-serine in adulthood (P56–P70), followed by a washout period of 1 week, and found no effect on behavior or electrophysiology.