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. Author manuscript; available in PMC: 2016 May 18.
Published in final edited form as: Mol Psychiatry. 2015 May 26;21(3):386–393. doi: 10.1038/mp.2015.61

Figure 4. Effect of neonatal D-serine treatment on PPI in adulthood.

Figure 4

D-serine 500 (mg/kg) was injected daily for 2 weeks starting on postnatal day 3. The PPI deficit was significantly rescued in adult Pick1 knockout mice treated with D-serine in the neonatal stage. Two-way repeated measures ANOVA of the data for knockout mice revealed a significant effect of treatment, F(1,99)=4.8, p=0.041. n=8, wild-type with saline treatment; n=8, wild-type with D-serine treatment; n=5, Pick1 knockout mice with saline treatment; n=13, Pick1 knockout mice with D-serine treatment.