Table 1.
Characteristics of the GHD patients at baseline and after 4 months of GHRT
| IS increased |
p values Start vs. 4 months |
IS decreased |
p values Start vs. 4 months |
p values IS decreased vs. increased 4 months |
|||
|---|---|---|---|---|---|---|---|
| GHRT start | GHRT 4 months | GHRT start | GHRT 4 months | ||||
| Sex (n) | 5 | 5 | |||||
| Male | 4 | 3 | |||||
| Female | 1 | 2 | |||||
| Age (years) | 35.0 ± 3.7 | 47.6 ± 6.5 | 0.10 | ||||
| BMI (kg/m2) | 27.1 ± 1.3 | 27.4 ± 1.5 | 0.63 | 25.5 ± 0.8 | 25.6 ± 1.0 | 0.70 | 0.30 |
| Lean mass (kg) | 55.7 ± 5.0 | 57.8 ± 5.4 | 0.13 | 56.1 ± 7.8 | 60.3 ± 8.8 | 0.09 | 0.79 |
| Waist (cm) | 93.8 ± 3.3 | 93.1 ± 3.9 | 0.53 | 95.9 ± 4.5 | 94.0 ± 4.9 | 0.29 | 0.88 |
| Fasted glucose (mM) | 4.6 ± 0.3 | 4.6 ± 0.3 | 0.56 | 4.6 ± 0.3 | 5.1 ± 0.1 | 0.13 | 0.07 |
| Fasted insulin (mU/l) | 4.8 ± 1.5 | 3.0 ± 1.4 | 0.01 | 5.0 ± 1.1 | 7.8 ± 1.6 | 0.02 | 0.03 |
| HOMA-IR | 1.0 ± 0.4 | 0.7 ± 0.4 | 0.01 | 1.1 ± 0.3 | 1.8 ± 0.3 | 0.01 | 0.04 |
| IGF1 (μg/l) | 104.8 ± 20.9 | 175.2 ± 23.6 | 0.06 | 93.0 ± 24.3 | 180.4 ± 29.0 | 0.01 | 0.88 |
| Triglycerides (mM) | 1.7 ± 1.0 | 0.9 ± 0.3 | 0.26 | 1.8 ± 0.2 | 2.1 ± 0.3 | 0.16 | 0.01 |
| NEFA (mM) | 0.5 ± 0.1 | 0.6 ± 0.1 | 0.78 | 0.7 ± 0.1 | 0.7 ± 0.0 | 0.58 | 0.12 |
| Total cholesterol (mM) | 4.9 ± 0.5 | 4.8 ± 0.9 | 0.92 | 5.5 ± 0.4 | 5.0 ± 0.4 | 0.07 | 0.83 |
| LDL (mM) | 3.4 ± 0.3 | 3.3 ± 0.8 | 0.86 | 3.9 ± 0.4 | 3.4 ± 0.4 | 0.01 | 0.85 |
| HDL (mM) | 1.2 ± 0.1 | 1.4 ± 0.1 | 0.18 | 1.2 ± 0.1 | 1.2 ± 0.1 | 0.86 | 0.25 |
Values shown are means ± SEM
Significant p-values (p<0.05) are indicated in italic font style