Table 2.

C3435T ABCB1 genotype and allele frequencies in relation to age at the onset of depression, severity of symptoms in HDRS score (HDRS I) and effectiveness of therapy as a change in HDRS score after treatment in depressed patients

ABCB1 3435			age at the onset of depression1
Genotype		n	median	min.	max.	quartile range	p value
CC		15	44.0	25.0	61.0	40.0 - 51.0	0.9819^^
CT		43	46.0	20.0	55.0	35.0 - 51.0
TT		32	46.0	14.0	58.0	35.5 - 52.0
C allele		n	median	min.	max.	quartile range
present		58	46.0	20.0	61.0	37.0 - 51.0	0.8728^
absent		32	46.0	14.0	58.0	35.5 - 52.0
T allele		n	median	min.	max.	quartile range
present		75	46.0	14.0	58.0	35.0 - 52.0	0.8881^
absent		15	44.0	25.0	61.0	40.0 - 52.0
HDRS I2
Genotype		n	mean	min.	max.	SD
CC		15	27.0	17.0	37.0	6.6	0.0106^^
CT		43	21.6	10.0	32.0	6.1
TT		32	20.5	7.0	37.0	7.7
C allele		n	mean	min.	max.	SD
present		58	23.0	10.0	37.0	6.6	0.2005*
absent		32	20.5	7.0	37.0	7.7
T allele		n	mean	min.	max.	SD
present		75	21.4	7.0	37.0	6.4	0.0026*
absent		15	27.0	17.0	37.0	6.6
HDRS change3
Genotype		n	median	min.	max.	quartile range
CC		13	21.0	6.0	27.0	16.0 - 23.0	0.0301^^
CT		41	14.0	5.0	26.0	10.0 - 16.0
TT		29	14.0	2.0	35.0	10.0 - 19.0
C allele		n	mean	min.	max.	SD
present		54	15.8	5.0	27.0	6.0	0.3447*
absent		29	14.4	2.0	35.0	7.3
T allele		n	mean	min.	max.	SD
present		70	14.6	2.0	35.0	6.3	0.0142*
absent		13	19.3	6.0	27.0	6.0

¹ The age of patients when depression start

² 17-item HDRS score prior to the start of medication (during the recurrence of depressive episode)

³ Difference between 17-item HDRS score after treatment (with selected combination of drugs) and HDRS I value