Body weight change in streptozotocin-induced type 1 DM mice. Mice were administered EGb 761 (50 mg/kg, p.o.) once a day for 10 consecutive days and then injected once with streptozotocin (120 mg/kg, i.p.). Thereafter, mice were re-administered EGb 761 (50 mg/kg, p.o.) again daily for an additional 10 days. The body weights are shown as mean±SEM of 7 mice. One-way ANOVA followed by Fisher's PLSD test was used for statistical analysis. Stz, streptozotocin; E, EGb 761; S, Saline. Stz+S group was compared to S+S. Stz+E group was compared to S+E group. * p <0.05.