Zhang 2006.
Methods | Design: parallel group randomised trial of peri‐operative azithromycin treatment. Eyes: bilateral cases both eyes included. |
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Participants | Country: Nepal Setting: field camps Number of participants: 109 (148 eyes operated) Lost to follow‐up: uncertain, as reported by eye rather than person Male: 29, Female: 80 |
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Interventions | (1) Bilamellar tarsal rotation with placebo (2) Bilamellar tarsal rotation with azithromycin, single dose |
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Outcomes | Primary outcome: recurrent trichiasis (1+ lash touching the eye) | |
Notes | Funder: Fight for Sight, International Trachoma Initiative, National Institutes of Health. | |
Risk of bias | ||
Bias | Authors' judgement | Support for judgement |
Random sequence generation (selection bias) | High risk | No random sequence. Patients allocated to azithromycin and placebo on an alternating basis. |
Allocation concealment (selection bias) | High risk | No concealment. |
Blinding of participants and personnel (performance bias) All outcomes | Low risk | Placebo used. |
Blinding of outcome assessment (detection bias) All outcomes | Low risk | Examinations by masked graders. |
Incomplete outcome data (attrition bias) All outcomes | Unclear risk | Some minor internal inconsistencies data. |
Selective reporting (reporting bias) | High risk | Excluded "surgical failures" from the analysis, defined as five+ lashes touching the globe at 3 months. |
TT = trachomatous trichiasis