Table 3.

Studies on hypofractionated SBRT for only lung metastases.

	Study year	No. of patients	No. of lung lesions	Primary site	Dose	LC	Toxicity
Norihisa et al.	2008	34	43	All (mostly from lung)	48 Gy/4 fr–60 Gy/5 fr within 4–18 days (median, 12 days)	2-year LC 90%	G2 12% G3 (pneumonitis) 3%
Rusthoven et al.	2009	38	63	All (mostly from colorectal)	48–60 Gy/3 fr	2-year LC 96%	G3 (pneumonitis) 2.6%
Oh et al.	2012	57	67	All (mostly from lung)	50–60 Gy/5–4 fr	3-year LC 94.5%	G2 (lung) 6% G5 in one pt Rib fractures 13%
Inoue et al.	2013	87	189	All (mostly from colorectal)	48 Gy/4 fr/4 days	2-year LC 80%	G3-4 10% (G4 in one pt)
Navarria et al.	2014	76	118	All (mostly from colorectal)	60 Gy/3 fr (peripheral)/3 days 48 Gy/4 fr (peripheral >2 cm) 4 days 60 Gy/8 fr (central)/10 days	2-year LC 89%	G1 80%