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Model for the regulation of BAP1-mediated deubiquitination by ASXL1/2. An intramolecular interaction involving UCH/CC1 and CTD domains of BAP1 creates an ASXM-inducible CUBI that facilitates ubiquitin binding and catalysis. The red asterisks indicate cancer-associated mutations of BAP1 or ASXM that disrupt the CUBI.
