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Oncogenic mutations disrupt the β sheet of HVR. The percent (%) of HVR β sheet was predicted using the DSSP (Dictionary of Secondary Structure of Proteins) method on the model 2 of wild-type, G12C, G12D, G12V, G13D, and Q61H K-Ras4B-GDP. The β sheet of HVR of K-Ras4BWT-GDP stems from six residues (residues 171–176) on the N-terminal HVR, which is impaired by the oncogenic mutations.
