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Effects of E37K and R164Q mutations on the dynamic behaviors of HVR. Backbone superimposition of simulated snapshots sampled at each 25-ns interval over 200 ns of simulation to the initial model in the models 1 and 2 of K-Ras4BE37K-GTP (A), the models 1 and 2 of K-Ras4BE37K-GDP (B), the models 1 and 2 of K-Ras4BR164Q-GTP (C), and the models 1 and 2 of K-Ras4BR164Q-GDP (D). The locations of mutation sites are colored in red.
