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The experimental NMR CSPs for K-Ras4BE37K-GDP. A, residual chemical shifts obtained after the overlay of 1H,15N HSQC NMR spectra of K-Ras4BWT-GDP and that of K-Ras4BE37K-GDP. The horizontal line in the graph shows the sum of mean CSP and S.D. The CSPs above the horizontal line are considered significant. A schematic representation of the regions undergoing significant CSPs (in magenta) are mapped on the models 1 (B) and 2 (C) of full-length K-Ras4B-GDP.
