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. 2015 Oct 7;290(48):29022–29034. doi: 10.1074/jbc.M115.670224

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© 2015 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 10. — Expression of JAK3 mutants in bone marrow cells of Balb/c mice leads to distinct leukemia phenotypes. Spleen and bone marrow cells of diseased animals were analyzed by flow cytometry with anti-CD4, anti-CD8, anti-Gr1, and anti-B220 antibodies. Cells were gated for GFP expression. FACS analysis representative of a CD8+ T-lymphoproliferation in a JAK3^V674A mouse (A), a CD4/8+ T-lymphoproliferation in a JAK3^L857P mouse (B), a Gr1+ myeloproliferation in a JAK3^L857P/Y100A mouse (C), a CD8+ T-lymphoproliferation in a JAK3^L857P/Y100A mouse (D), and a B220+ B-lymphoproliferation in a JAK3^L857P mouse (E) are shown, either as dot plots (spleen) or as stacked column charts representing the percentage of cells positive for the different markers (bone marrow).