TABLE 2.

Expression of JAK3 mutants in bone marrow cells of Balb/c mice leads to distinct leukemia phenotypes

The table shows the days post-transplant at sacrifice, the white blood cells count at sacrifice, and the diagnosis of Balb/c mice receiving a bone marrow transplantation of lineage negative cells expressing JAK3^V674A, JAK3^L857P or JAK3^L857P/Y100A. Five different diagnosis were observed: CD8+ T-lymphoproliferation in JAK3^V674A mice (Bracket A), CD4/8+ T-lymphoproliferation in JAK3^L857P and JAK3^L857P/Y100A mice (Bracket B), Gr1+ myeloproliferation in JAK3^L857P and JAK3^L857P/Y100A mice (Bracket C), another type of CD8+ T-lymphoproliferation in JAK3^L857P and JAK3^L857P/Y100A mice (Bracket D), and B220+ B-lymphoproliferation in a JAK3^L857P mice (Bracket E).